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						<h1 itemprop="headline">Distinguished iNANO lecture by Paolo Decuzzi, Italian Institute of Technology and Stanford University</h1>
						

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							<p class="text--intro" itemprop="description">Microstructured Drug Delivery Platforms for Complex Combination Therapies in Cancer and Chronic Inflammatory Disorders</p>
						
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														Friday  6  December 2024,
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														&nbsp;at 10:15 -  11:00
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														<p>iNANO AUD (1593-012)</p>
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														Associate Professor Ken Howard (kenh@inano.au.dk)
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														<span itemprop="name">Trine Møller Hansen</span>
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                    <h3><a href="https://www.iit.it/people-details/-/people/paolo-decuzzi" target="_self">Paolo Decuzzi,&nbsp;Senior Researcher Tenured - Principal Investigator, Italian Institute of Technology and Stanford University</a></h3>
<p><br> <strong>Microstructured Drug Delivery Platforms for Complex Combination Therapies in Cancer and Chronic Inflammatory Disorders</strong></p>
<p>Despite significant advancements in early diagnosis, targeted therapies, robot-assisted and image-guided surgery, and the advent of immunotherapies, high-grade gliomas, chronic inflammatory joint diseases, and other medical disorders remain incurable. Drug delivery systems and nanomedicine could play a crucial role in addressing these challenging medical conditions.</p>
<p>This lecture demonstrates the fundamental importance of such a multidisciplinary approach by reviewing a few examples of nanomedicines and multiscale drug delivery systems developed over the past 10 years. Examples include: <em>microMESH</em>, a regular network of microscopic polymeric filaments designed for treating glioblastoma and other tumors through complex immunochemotherapies; <em>microPLates</em>, shape-defined polymeric particles engineered for the pharmaco-mechanical and anti-inflammatory treatment of osteoarthritis; <em>micro-Combinatorial hydroGel Particles</em>, spongy discoidal carriers designed for the precise delivery of potent chemotherapeutic agents, targeting cancer metastasis within the pulmonary microvasculature.</p>
<p>Through these examples, basic concepts in nanomedicine and drug delivery will be introduced and the potential of hierarchical-organized platforms, enabling the precise deployment of complex therapeutic regimens, will be demonstrated to address biophysical barriers and biological heterogeneity in cancer, chronic inflammatory diseases and other medical disorders.</p>
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    <p><strong>References</strong><br> Di Mascolo D, Guerriero I, Pesce C, Spanò R, Palange AL, <strong>Decuzzi P.</strong> μMESH-Enabled Sustained Delivery of Molecular and Nanoformulated Drugs for Glioblastoma Treatment.&nbsp;<em>ACS Nano</em>. 2023 Aug 8;17(15):14572-14585.<br> Palange AL, Mascolo DD, Ferreira M, Gawne PJ, Spanò R, Felici A, Bono L, Moore TL, Salerno M, Armirotti A, <strong>Decuzzi P.</strong> Boosting the Potential of Chemotherapy in Advanced Breast Cancer Lung Metastasis via Micro-Combinatorial Hydrogel Particles. 2023 Apr;10(10):e2205223<br> Gawne PJ, Ferreira M, Papaluca M, Grimm J, <strong>Decuzzi P</strong>. New Opportunities and Old Challenges in the Clinical translation of Nanotheranostics. <em>Nat Rev Mater</em>. 2023 Dec;8(12):783-798<br> Bedingfield SK, Colazo JM, Di Francesco M, Yu F, Liu DD, Di Francesco V, Himmel LE, Gupta MK, Cho H, Hasty KA, <strong>Decuzzi P</strong>, Duvall CL. Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis. <em>ACS Nano</em>. 2021 Sep 28;15(9):14475-14491<br> Di Mascolo D, Palange AL, Primavera R, Macchi F, Catelani T, Piccardi F, Spanò R, Ferreira M, Marotta R, Armirotti A, Gallotti AL, Galli R, Wilson C, Grant GA, <strong>Decuzzi P.</strong> Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours. <em>Nat Nanotechnol.</em> 2021 Jul;16(7):820-829.</p>


            
                



            
            
                



            
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