Info about event

Time

Friday 11 April 2025, at 10:15 - 11:00

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Location

iNANO Auditorium (1593-012)

Organizer

Brigitte Maria Städler

By Fie Noer Christensen

Tenure Track Assistant Professor Thibault Viennet, iNANO/Dept. of Chemistry, Aarhus University

“Unstructural” biology to understand protein regulation

It is well established that about 40% of all protein regions do not adopt stable 3D structures: they are disordered. The most striking feature of these disordered domains is that they are targets of post-translational modifications much more than structured domains. These modifications are critical regulatory processes and imbalances often lead to disease. However, the mechanisms by which these modifications affects protein disordered regions to change their function are largely elusive. Studying the conformation of disordered regions and their dynamics presents a challenge that is intractable by many structural biology techniques but can be tackled by Nuclear Magnetic Resonance (NMR). In my lab, we use NMR to explore the molecular determinants of protein regulation by phosphorylation, especially in transcription factors, a class of proteins with particularly high amount of disorder and elusive regulatory motifs.

Tenure Track Assitant Professor Anna Louise Duncan, iNANO/Dept. of Chemistry, Aarhus University

Molecular modelling of complex and crowded biomembranes