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						<h1 itemprop="headline">Lecture by Hideki Yorimitsu, Department of Chemistry, Kyoto University</h1>
						
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							<p class="text--intro" itemprop="description">Aromatic Metamorphosis: Skeletal Transformations of Aromatic Rings</p>
						
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														Thursday  3  September 2026,
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														Yonghui Zhang
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									<h2><a href="https://inano.au.dk/about/news-events/news/show/artikel/lecture-by-hideki-yorimitsu-department-of-chemistry-kyoto-university" target="_self"><span data-ogsc="rgb(36, 36, 36)"><strong>Hideki&nbsp;Yorimitsu</strong></span></a></h2>
<p>Host: Yonghui Zhang</p>
<p class="x_elementtoproof"><strong>Aromatic Metamorphosis: Skeletal Transformations of Aromatic Rings</strong></p>
<p class="x_elementtoproof">Department of Chemistry, Kyoto University</p>
<p class="x_elementtoproof"><a href="mailto:yori@kuchem.kyoto-u.ac.jp" title="mailto:yori@kuchem.kyoto-u.ac.jp" data-linkindex="2" data-ogsc><u>yori@kuchem.kyoto-u.ac.jp</u></a></p>
<p class="x_elementtoproof"><strong>Abstract</strong></p>
<p class="x_elementtoproof">Aromatic skeletons are generally resistant to cleavage due to their high stabilization energy and strong endocyclic bonds. While exocyclic functionalizations are well explored, endocyclic modifications via partial disassembly and ring reconstruction remain less studied. Here, I disclose our efforts to establish 'aromatic metamorphosis',<sup data-ogsc>1</sup>&nbsp;a strategy that transforms common aromatic compounds such as thiophenes, benzofurans, and indoles into distinct ring systems through multi-step or ideally single-step processes. Aromatic metamorphosis, or what we may now call skeletal editing<sup data-ogsc>2</sup>&nbsp;of an aromatic ring,<sup data-ogsc>&nbsp;</sup>challenges traditional frameworks in organic chemistry and provides new efficient or sustainable tools for synthesizing otherwise inaccessible heterocycles and generating chemical libraries with diverse endocyclic frameworks.<sup data-ogsc>3,4</sup></p>
<p class="x_MsoNormal">&nbsp;</p>
<p class="x_MsoNormal">References</p>
<p class="x_MsoNormal">1. K. Nogi, H. Yorimitsu, Chem. Commun. 2017, 53, 4055; H. Yorimitsu, Acc. Chem. Res. 2025, 58, 1323.</p>
<p class="x_MsoNormal">2. a) J. Jurczyk, J. Woo, S. F. Kim, B. D. Dherange, R. Sarpong, M. D. Levin, Nat. Synth. 2022, 1, 352; b) B. W. Joynson, L. T. Ball, Helv. Chim. Acta 2023, 106, e202200182; c) M. D. Levin, Synlett 2024, 35, 1471.</p>
<p class="x_MsoNormal">3. Representative examples about endocyclic substitution: a) D. Vasu, H. Yorimitsu, A. Osuka, Angew. Chem. Int. Ed. 2015, 54, 7162; b) M. Bhanuchandra, K. Murakami, D. Vasu, H. Yorimitsu, A. Osuka, Angew. Chem. Int. Ed. 2015, 54, 10234; c) A. Kaga, K. Nogi, H. Yorimitsu, Chem. Eur. J. 2019, 25, 14780; d) T. Yanagi, T. Tanaka, H. Yorimitsu, Chem. Sci. 2021, 12, 2784.</p>
<p class="x_MsoNormal">4. Representative examples about insertion: a) H. Saito, S. Otsuka, K. Nogi, H. Yorimitsu, J. Am. Chem. Soc. 2016, 138, 15315; b) S. Tsuchiya, H. Saito, K. Nogi, H. Yorimitsu, Org. Lett. 2017, 19, 5557; c) S. Tsuchiya, H. Saito, K. Nogi, H. Yorimitsu, Org. Lett. 2019, 21, 3855.</p>
								
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